SRC and cancer: MTT assay and western blot results showed that excessive matrine treatment could obviously inhibit the cell proliferation and decrease the phosphorylation levels of various signaling proteins in cancer cells overexpressing pcDNA3.1-HA-SRC-WT, but failed to do so in cancer cells overexpressing pcDNA3.1-HA-SRC-A392G (Fig. 6E and Supplementary Figs. S7 and S8).