EGFR and familial pancreatic carcinoma: Subsequently, human cervical cancer cell HeLa, gefitinib-resistant human lung cancer cell PC-9-IR (mutant of EGFR, upstream protein of Src kinase), and human pancreatic cancer cell AsPC-1 (mutant of Ras, downstream protein of Src kinase) were transfected with plasmid pcDNA3.1-HA-Src, and then treated with matrine or KX2-391, respectively.