In our study, by measuring the SIRT1 expression in CRC cells co-transfected with vectors carrying FBXW11 and HIC1, and analyzing the correlations of FBXW11, HIC1, and SIRT1 expressions in colorectal tumors, we deduced that FBXW11 upregulated the expression of SIRT1 in CRC cells via reducing the stability of HIC1. The gene discussed is SIRT1; the disease is colorectal neoplasm.