A previous review reports that WNT4 dysregulation during the embryonic period may result in male-to-female sex reversal [2], which is critical in the development of sexual organs and mammary glands [3], while a decreased expression of WNT4 polymorphism is associated with reduced bone density with premature skeletal aging [4], endometriosis in infertile patients [5], and gynecological malignancies [6]. The gene discussed is WNT4; the disease is Infertility.