The oncogenic role of protein arginine methyltransferase 5 (PRMT5) could activate the WNT4/β-catenin signaling pathway to induce laryngeal carcinoma cell proliferation, migration, and invasion in vitro, as well as lymph node metastasis in vivo [95], while silencing WNT4 could reverse the effect of PRMT5. The gene discussed is PRMT5; the disease is laryngeal carcinoma.