HLA-C and neoplasm: For example, all tumor epithelial clusters exhibited upregulation of immune-related pathways such as “antigen presentation: folding, assembly, and peptide loading of class I MHC.” However, only EpiC3 exhibited upregulation of “MHC class II antigen presentation” and downregulation of “citric acid (TCA) cycle and respiratory electron transport” (Supplementary Table S5).