HNF4A and gastric cancer: In a second independent bulk RNA-seq data set (gastric cancer TCGA), we further confirmed increased KLF2 expression in diffuse-type compared with intestinal-type tumors (P = 0.00013), with boundaries of variance similar to with other credentialed oncogenes such as ERBB2 and HNF4α associated with intestinal-type gastric cancer (Fig. 3F; Supplementary Fig. S5F; refs. 42, 43).