A 3.5 to 7-year-long study conducted on marmosets intracerebrally inoculated with large volumes of AD brain extracts (300 μl of 10% homogenates distributed within 6 inoculation sites) led to moderate Aβ deposition in most animals but not to tau pathology nor to other AD-like pathological features [2, 23, 34]. Here, MAPT is linked to Alzheimer disease.