MAPT and Alzheimer disease: In AD-inoculated animals, tau pathology was detected using AT8 that detects phosphorylation of S202 and T205 [38] (Figs. 6, 7), AT100 that detects phosphorylation at T212 and at S214 that is phosphorylated in AD brains but not in normal brains [38] (Fig. 6d, g), an anti-pS422 antibody (phosphorylation at S422 occurs in AD but not in normal brains [38], Fig. 6c, f), and Gallyas silver staining (Fig. 6h).