Molenaar et al. described a germline IDH2 mutation, c.782G > A (p.Arg261His), in a patient with AML, and another germline mutation, c.1304 C > T (p.Thr435Met), in two unrelated patients with MDS (RCMD - Refractory Cytopenia with Multilineage Dysplasia) [36]. This evidence concerns the gene IDH2 and acute myeloid leukemia.