These lower shear stresses promoted internalization of E-cadherin in metastatic esophageal cancer cells [61, 64], highlight the importance of Caveolin-1 as a key mechanosensor during hematogenous metastasis [62], and induced EMT in 3D ovarian cancer nodules by downregulating E-cadherin and upregulating Vimentin both at the transcript and protein levels [14]. The gene discussed is VIM; the disease is esophageal cancer.