SAMHD1 and acute myeloid leukemia: Although cellular SAMHD1 levels, but not those of DCK that is critical for CNDAC phosphorylation and activation [[15, 28]; Wu et al., 2021], predominantly determined CNDAC sensitivity in CNDAC-naïve cells, the establishment of 24 CNDAC-resistant AML sublines unanimously resulted in a loss of DCK but not in an increase of SAMHD1.