In contrast to the CNDAC-adapted AML cell lines introduced here, which displayed reduced DCK expression as main acquired resistance mechanism, AML cell lines adapted to the SAMHD1 substrates cytarabine or decitabine were characterised by a combination of increased SAMHD1 levels and decreased DCK levels [36, 41]. This evidence concerns the gene SAMHD1 and acute myeloid leukemia.