SAMHD1 and acute myeloid leukemia: However, data from a large range of cell line models (including clonal AML sublines characterised by varying SAMHD1 levels) and patient samples demonstrated that high SAMHD1 levels are associated with reduced CNDAC sensitivity and that CRISPR/Cas9-, siRNA-, and VPX-VPL (virus-like particles carrying the lentiviral VPX protein)-mediated SAMHD1 depletion increase cellular CNDAC-TP levels and sensitise AML cells to CNDAC.