CD8+GranzB+CTLs in pSS patients seemed to show similar effects as CD4+GranzB+CTLs by using mono-factor analysis, while, after excluding the classical risk factors in pSS patients by using multivariate regression analysis, CD8+GranzB+CTLs only showed correlation with CD4+GranzB+CTLs and ESR independently, having no association with ESSDAI and extraglandular manifestations in pSS patients. This evidence concerns the gene CD4 and peeling skin syndrome.