T cell infiltration can also been detected in dry eye patients with or without a systemic autoimmune disease, and an adaptive CD4+ T cell autoimmune response was following the initial innate immune response to dryness in mice exposed to desiccating stress and patients with pSS and non-SS-associated aqueous tear deficiency [29, 30]. This evidence concerns the gene CD4 and Keratoconjunctivitis sicca.