Extraglandular involvements in pSS patients were the dependent variable, while age, gender, and pSS-related factor such as IgG, IgA, IgM, C3, C4, ESR, anti-SSA, anti-SSB, ESSPRI, ESSDAI, PGA, CD8+GranzB+CTLs, and CD4+GranzB+CTLs were as independent variables. This evidence concerns the gene C4A and peeling skin syndrome.