Besides, the present study is the first to provide evidence that the Wnt-β-catenin-mediated EMT and metastasis by FAM83A in HNSCC, and there may be a potential bi-directional signaling loop between FAM83A and Wnt/β-catenin signaling pathway (Additional file 3: Figure S3). This evidence concerns the gene SACK1A and head and neck squamous cell carcinoma.