GSK3B and familial pancreatic carcinoma: GSK3β phosphorylates β-catenin and results in the degradation of β-catenin, which inhibits the activity of the Wnt signaling pathway [30–32] Interestingly, it has been reported that the overexpression of FAM83A could interact with the Wnt/β-catenin signaling pathway in pancreatic cancer and lung cancer [6].