Although there is an increasing amount of evidence that supports the use of glyburide or metformin for GDM, the American Diabetes Association (ADA) and American College of Obstetricians and Gynecologists (ACOG) still recommend insulin as the primary medical treatment if the glycaemic treatment goals are not achieved with life-style intervention, due to the lack of evidence regarding the long-term safety of the alternatives [21, 22]. Here, INS is linked to gestational diabetes.