In patients over 75 years-old undergoing surgical aortic valve replacement with CPB and experiencing CS-AKI with an incidence which is in line with recent studies using the same modern definition [1–3, 18], ∆pCrpostCPB-H6 outperformed TIMP2 IGFBP7 at H6 for the early recognition of CS-AKI. Here, TIMP2 is linked to Cowden syndrome 1.