There was a marked overlap between TIMP2 IGFBP7 measurements at H6 in patients who developed CS-AKI and those who did not (Fig. 2) and the associated AUCROC to detect CS-AKI was only fair (AUCROC = 0.64 [95%CI 0.51;0.76]). This evidence concerns the gene TIMP2 and Cowden syndrome 1.