According to our research results, it is found that some single nucleotide polymorphisms (ADIPOR2 rs1044471, PCK1 rs1042531, GLUT1 rs12718444) in the adiponectin signalling pathway may be associated with T2DM.Linkage disequilibrium analysis and haplotype-based association analysis showed that there was a linkage disequilibrium between the two loci in 9 genes such as ADIPOQ in the pathway. The gene discussed is PCK1; the disease is type 2 diabetes mellitus.