The human body may be able to increase circulating ADIPO through some negative regulation, thereby ameliorating the ADIPOR2 gene variant (rs1044471) resulting in a decrease in insulin sensitivity [42].Our findings also proved that ADIPOR2 rs1044471 may be related to the occurrence and development of T2DM, which further supported the research results of Martine Vaxillaire [43]. This evidence concerns the gene INS and type 2 diabetes mellitus.