ADIPOQ and type 2 diabetes mellitus: Multiple gene SNPs in the adipocytokine signalling pathway have been shown to be significantly associated with the risk of developing T2DM, for example, 3 SNPs (rs10789038, rs2796498, and rs2746342) of the PRKAA2 gene [23,24], 3 SNPs (rs1800206, rs4253776 and rs4253778) of the PPARA gene in the ADIPO signalling pathway [25] and 5 SNPs (rs1501299, rs17300539, rs2241766, rs266729 and rs16861194) of the ADIPOQ [26–29].