However, CBD could not alter the conductance of voltage-gated sodium (Nav) current in both excitatory and inhibitory neurons differentiated from the patient-derived iPSCs, although previous studies showed that the haplo-insufficient mutation of the Nav1.1-encoding SCN1A gene affected the Dravet syndrome [70,71]. This evidence concerns the gene SCN1A and encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.