TNF and ulcer disease: Additionally, higher healing rates and total remission rates of peptic ulcers were evidenced, and different scenarios for the mechanisms involved in ulcer response were proposed: (i) the activation of NF-Kβ was inhibited by allicin, which further inhibits the production of TNF-α, leading to anti-inflammatory effects; (ii) garlic extracts possess a protective role against oxidative stress in gastric tissue, which cause mucosal injury and ulcer development; (iii) garlic extracts favors NO synthesis, increasing the activity of nitric oxide synthase with crucial role in endothelial function [98].