Indeed, it showed anti-angiogenesis effects by counteracting tube formation of HUVECs endothelial cell line and cell cancer migration through downregulation of matrix metalloproteinase-9 (MMP-9) expression in MDA-MB-231 cells, thus revealing a potential therapeutic agent in triple-negative breast cancer metastasis [84]. This evidence concerns the gene MMP9 and triple-negative breast carcinoma.