The depletion of liver fibrosis in mice given a polydatin-loaded micelle (PD-MC) was verified by measuring hydroxyproline and fibrotic parameters, including collagen type 1 (Col1), tissue inhibitor of metalloproteinases 1 (TIMP-1), transforming growth factor-beta (TGF-β), and PD-MC, which not only inhibited hepatocyte apoptotic cell death but also showed anti-inflammatory properties. Here, TIMP1 is linked to Hepatic fibrosis.