Considering the role of cell adhesion molecules (CAMs) in developing ischemia/reperfusion-induced cerebrovascular diseases in a rat MCAO model, Cheng et al. found that polydatin can reduce the volume of brain infarction by decreasing the levels of CAMs in comparison to the control group, as well as the involvement of E-selectin, L-selectin, integrins, ICAM-1, and vascular cell adhesion molecule-1 (VCAM-1) [85]. This evidence concerns the gene VCAM1 and cerebrovascular disorder.