Cordycepin was also found to sensitize human hepatocellular carcinoma (Hep3B) cells to TRAIL-mediated apoptosis by co-treating with TRAIL, which leaded to pro-apoptosis up-regulation and anti-apoptosis protein down-regulation via decreasing JNK phosphorylation [40]. The gene discussed is TNFSF10; the disease is hepatocellular carcinoma.