Some human proteins have been identified as key regulators in the development of diabetes like glucokinase, AMP-activated protein kinase, 11 β-hydroxysteroid dehydrogenases (11 β-HSD), insulin receptor substrate, interleukin1 beta, dipeptidyl peptidase IV, glutamine-fructose-6-phosphate amidotransferase (GFAT), peroxisome proliferator-activated receptor-gamma (PPAR-gamma), tyrosine phosphatases, tyrosine kinase insulin receptor, protein kinase B, and insulin receptor [3]. The gene discussed is GCK; the disease is diabetes mellitus.