It is a heterogeneous disease involved with inherited mutations in susceptibility genes, such as p53 tumor suppressor gene, ERBB2, and PIK3CA oncogenes, etc. Approximately 10% of ovarian cancer occurs in women carrying BRCA1 or BRCA2 mutations [5,6], causing some ovarian cancers clustering in families. The gene discussed is TP53; the disease is ovarian carcinoma.