For example, the splicing factor 3b (SF3b) complex, a representative spliceosomal component, is the most frequently mutated splicing factor in cancers [5] such as myelodysplastic syndromes [6], acute myeloid leukemia (AML) [7], chronic lymphocytic leukemia (CLL) [8], and various solid tumors [9,10,11]. The gene discussed is SLU7; the disease is acute myeloid leukemia.