PTGS2 and rheumatoid arthritis: Some derivatives serve as oral diuretics (furosemide, indapamide, chlorthalidone, thiazides); anticancer (E7070), carbonic anhydrase (CA) inhibitors (acetazolamide, dichlorophenamide, dorzolamide and brinzolamide), antiepileptics (zonisamide and sulthiame), antiviral (darunavir), anti-inflammatory (celecoxib), antibacterial (sulfadizine), anticonvulsant (zonisamide) and cyclooxygenase-2 (COX-2) inhibitors (valdecoxib), while the others are used as ophthamologicals (dorzolamide) and for the treatment of rheumatoid arthritis (sulfasalazine) [5].