Other frequently noted changes in connection with cell migration were a reduction in the active form of Focal Adhesion Kinase (FAK, PTK2), a key player in metastatic cancer [74,78,79,80,81], and upregulation of the epithelial marker E-cadherin, suggesting a reversal of the epithelial-mesenchymal transition [66,73,77]. This evidence concerns the gene PTK2 and metastatic malignant neoplasm.