IL33 and Alzheimer disease: Among them, we have recently demonstrated that oral administration of lycoperoside H, a steroidal saponin isolated from tomato seeds, ameliolated atopic dermatitis (AD)-like skin inflammation and transepidermal water loss (TEWL), in concert with a decrease in accumulation of mast cells, eosinophils in dermis, the secretion of serum total IgE, and the Th2/Th1 cytokine ratio in IL-33 transgenic mice [10].