HMGB1 and cancer: In our previous study, we showed that cancer cells subjected to PDT with two compounds of cyanoarylporphyrazine group with 9-phenanthrenyl and 4-(4-fluorobenzyoxy)phenyl substituted in the aryl frame of the macrocycle demonstrate typical features of ICD: release of crucial DAMPs (e.g., ATP and HMGB1), which induce activation and maturation of dendritic cells in vitro [11].