Subsequently, we proved that in HG-3 cells, also derived from a patient affected by CLL, quercetin enhanced apoptosis in the presence of ABT-737 by directly inhibiting the CK2 and PI3K protein kinases and, as a consequence, inactivating the PI3K/AKT/Mcl-1 signaling pathway that in CLL is often associated with drug resistance [4]. This evidence concerns the gene AKT1 and B-cell chronic lymphocytic leukemia.