However, the inactivation of AKT phosphorylation by STL1 was not sufficient to induce cell death in the malignant cell line investigated as represented by the HG-3 cells, a lymphoblastoid cell line with B1 cell characteristics established from a CLL clone by the in vitro EBV infection [24]. The gene discussed is AKT1; the disease is B-cell chronic lymphocytic leukemia.