Treatment by intraperitoneal perfusion with elemene in colorectal cancer patients showed that compared with the control group, the CD4+/CD8+ T cells as well as NK cells gradually increased in the elemene-treated group, suggesting that elemene contributes to the improvement of cellular immune function, and that the IL-2 level can be obviously increased by the elemene-treated group, while exerting an inhibitory effect on IL-10 and TNF-α, indicating that elemene elevates the humoral immune function [137]. This evidence concerns the gene CD4 and colorectal cancer.