In the study of the treatment of β-elemene–paclitaxel on tumor angiogenesis-related gene expression, the expression of G-protein coupled receptor 124 (GPR124), MMP-3, and MMP-9 genes and protein decreased, while the expression of endostatin, TIMP metallopeptidase inhibitor (TIMP)-1, and TIMP-2 increased in U-2OS cells. The gene discussed is ADGRA2; the disease is neoplasm.