Compared with the control group and Apatinib group, the numbers of metastatic tumor nodules were significantly decreased, the expression of miR-1323 was decreased, and Cbl-b and E-cadherin were significantly upregulated in the lungs of nude mice treated with β-elemene, whereas vimentin, MMP-2, and MMP-9 were significantly downregulated. This evidence concerns the gene CDH1 and neoplasm.