TFRC and nutritional disorder: In terms of the effect of the IRPs on IRE-containing mRNA’s, under conditions of cellular iron deficiency, IRP-binding to the IREs in the 3ꞌ-UTR increases transferrin receptor 1 (TfR1) mRNA stability, leading to increased uptake of iron from transferrin (Tf) via receptor-mediated endocytosis of the Tf-TfR1 complex [93,94,95].