Indeed, the Western blotting data shown in Figure 11, revealed an increase in phospho-H3-Ser10 expression in the breast and lung cancer cell lines treated with CAs, whereas the expression of Mdm2, phospho-Cdk-Tyr15, and both cyclins B1 and A2 substantially decreased after CA treatment (Figure 12). This evidence concerns the gene MDM2 and lung carcinoma.