These two single-nucleotide polymorphisms (SNPs) are also associated with the occurrence of HCC, while methylenetetrahydrofolate reductase (MTHFR) rs1801133 and epidermal growth factor (EGF) rs4444903 may further add to the HCC risk [9,10,11,12,13]. Here, EGF is linked to hepatocellular carcinoma.