The use of antihypertensive drugs in hypotensive sepsis is counterintuitive but beneficial (“inverted therapy” [154]: ergotoxine [115], chlorpromazine [6,16,106], phenoxybenzamine [5,151,152], beta-blockers [155,156,157,158,159,160,161], and alpha-2 agonists [111,162,163,164,165,166,167,168,169,170,171]). The gene discussed is PSMA2; the disease is Sepsis.