In our cohort of HF patients who initiated chronic HD, one-year mortality was highest in older patients (79.8 ± 7.2 versus 72.9 ± 10.9 years, p < 0.001; aOR 1.07 (1.03–1.12), p = 0.002), as well as in patients with lower serum albumin levels (3.1 ± 0.6 g/dL versus 3.4 ± 0.6 g/dL; p < 0.001; aOR 0.38 (0.22–0.66, p = 0.001) and lower serum creatinine levels (5.1 ± 1.6 mg/dL versus 5.8 ± 2.0 mg/dL; p = 0.021; aOR 0.80 (0.65–0.97), p = 0.022). This evidence concerns the gene ALB and hydrops fetalis.