ALB and Cognitive impairment: The majority of the studies investigated frailty using single markers of frailty, such as physical functionality (e.g., gait speed, handgrip strength), blood parameters (serum albumin), impairments in activities of daily living (ADL), nutritional status/risk (Mini-Nutritional Assessment), cognitive impairments (Mini-Mental State Examination) and body composition (Psoas muscle area index), as shown in Table 1.