SERPINA1 and COVID-19: In parallel with the distribution of AAT mutations following a north-to-south gradient, with 47% of the total number registered in the Lombardia region (237 out of 508) [26], an inhomogeneous distribution of COVID-19 cases was reported, with 85% of the total fatal cases registered in northern Italy (51.9% in the Lombardia region in particular) and an abrupt decrease from north to south.