From a clinical point of view, it should be noted that in patients with COVID-19 who were admitted to the intensive care unit (ICU), higher ratios of interleukin (IL) 6 to α1-antitrypsin predicted a prolonged ICU stay and higher mortality, whereas lower ratios of IL-6 to α1-antitrypsin were associated with clinical resolution [3]. This evidence concerns the gene IL6 and COVID-19.