PLAUR and COVID-19: Interestingly, in the studies by the research group of Giamarellos-Bourboulis [23,25] a biomarker indicating a high probability of future hyperinflammation syndrome (soluble urokinase plasminogen activator receptor (suPAR)) was used to guide therapeutic decisions, possibly allowing the administration of anakinra earlier in the course of COVID-19 before clinical establishment of severe disease.