Jude Total XV protocol, which uses a higher dose of asparaginase during induction (10,000 UI/m2 on Days 6, 8, 10, 12, 14, and 16) than that used in the ALL IC BFM 2002 protocol (5000 UI/m2 on Days 12, 15, 18, 21, 24, 27, 30, and 33), and reported a higher incidence of clinical allergy (41%) [27]. This evidence concerns the gene ASPG and acute lymphoblastic leukemia.