CRP and bacterial infectious disease: As in the European cohort, patients with ACLF were younger, had a more severe grade of systemic inflammation (as demonstrated by higher levels of white blood cells and CRP) and more frequently had a bacterial infection (associated or not with HBV reactivation) as precipitant compared to those without ACLF, with a significantly higher short-term mortality (52.1% vs. 4.3%) [6].