Furthermore, a slightly positive correlation of Metrnl with the immune-regulatory adipokine progranulin was observed exclusively in LCD patients, whereas there were no significant correlations with C1q/TNF-related protein-3 (CTRP-3), cathelicidin antimicrobial peptide (CAMP) and fibroblast growth factors (FGF) 19 and 21 (Table 2) in both cohorts. This evidence concerns the gene C1QTNF3 and lattice corneal dystrophy type I.