HSD11B1 and metabolic syndrome: In an association analysis, they showed that HSD11B1 rs12086634 TG contributes to an increased risk of both T2D (OR = 1.91; 95% CI 1.33–2.76, p = 0.0005) and MetS (OR = 2.37; 95% CI 1.39–4.05, p = 0.0015).