Studies highlighting Rv2026c along with Rv2421c (probable nicotinate-nucleotide adenylyltransferase) as two novel biomarkers for TB diagnosis have shown that among other identified antigens, these two exhibited the best diagnostic performance, as they were both recognized by IgG and IgM antibody responses, with Rv2026c exhibiting considerably higher IgG antibody levels in active TB patients in comparison to healthy controls, while Rv2421c yielded higher levels for both antibody levels in active TB patients [70]. This evidence concerns the gene CD40LG and tuberculosis.