It is worth mentioning that moderate-intensity treadmill exercise over 4 weeks was generally demonstrated to significantly inhibit the overactivation of the NLRP3 inflammasome of mice and rats in adipose tissue [49,50], liver [51,52], myocardium [53,54,55] hippocampus [56,57,58,59,60,61], prefrontal cortex [63] and substantia nigra [62] which were caused by metabolic disorder, DEN (diethylnitrosamine) damage, hypoxia, myocardial hypertrophy, aging, myocardial infarction, ovariectomy, Alzheimer’s’ disease, depression, cerebral ischemia and ischemia reperfusion. The gene discussed is NLRP3; the disease is major depressive disorder.