Based on these results, Zaidi [70] and Quiroga [71] investigated the combined effect of chronic endurance and resistance training on the NLRP3 inflammasome activation, and the activity of NLRP3 was significantly blunted in PBMCs of obese children despite no effect on adults with T2DM and coronary artery disease. The gene discussed is NLRP3; the disease is type 2 diabetes mellitus.