It is worth mentioning that moderate-intensity treadmill exercise over 4 weeks was generally demonstrated to significantly inhibit the overactivation of the NLRP3 inflammasome of mice and rats in adipose tissue [49,50], liver [51,52], myocardium [53,54,55] hippocampus [56,57,58,59,60,61], prefrontal cortex [63] and substantia nigra [62] which were caused by metabolic disorder, DEN (diethylnitrosamine) damage, hypoxia, myocardial hypertrophy, aging, myocardial infarction, ovariectomy, Alzheimer’s’ disease, depression, cerebral ischemia and ischemia reperfusion. Here, NLRP3 is linked to metabolic disease.