IGHE and airway hyperresponsiveness: Furthermore, licochalcone A obviously improved allergic inflammation through suppression of airway hyperresponsiveness, OVA-specific antibodies (IgG, IgG1, and IgE), and Th2 cytokines, which are comprised of IL-13, IL-5, and IL-4, while attenuating eosinophil infiltration and mucus hypersecretion in an OVA-induced asthma mouse model compared with normal mice [14,22].