In particular, deletion of the ORAI1 gene in CD4+ T-cells has been reported to decrease the severe levels of experimental autoimmune encephalomyelitis and inflammation of the central nervous system via suppression of SOCE, as SOCE is involved in reducing the secretion of proinflammatory cytokines in Th1 and Th17 cells [28]. Here, ORAI1 is linked to experimental autoimmune encephalomyelitis.