TNF and mastitis: Specifically, licochalcone A has been reported to suppress the production of several proinflammatory mediators (IL-1β, PGE2, IL-6, NO, LTB4, COX-2, iNOS, and TNF-α) in different situations, including IL-1β-induced chondrocytes, N-formyl-MET-LEU-PHE, lipopolysaccharide (LPS), UVB-induced skin cell types (keratinocytes, granulocytes, fibroblasts, and dendritic cells), and the LPS-stimulated mouse mastitis model [16,17,19].