About the areas involved in the GAL(1-15)-SSRI interaction in the OBX animal, the coadministration of GAL(1-15)+ESC in OBX rats produce a significant increase in the number of c-Fos-IR profiles in several nuclei involved in MDD: dorsal hippocampus, PFC, and LHb. The gene discussed is FOS; the disease is major depressive disorder.