GAL and major depressive disorder: With regard to the other functional network (Factor 1), comprised for LHb, DR, and VTA, we have previously described an essential role of DR in the depression and anxiety-like behaviours induced by GAL(1-15) [22], and also this nucleus participates in the enhancement of the antidepressant-like actions of a 5-HT1AR agonist in the FST by GAL(1-15) [23].