FOS and major depressive disorder: We have analysed c-Fos immunoreactivity (c-Fos-IR) 90 min after the coadministration of icv GAL(1-15) and the three ip injections of ESC (10 mg/kg) in OBX rats in several nuclei involved in MDD: Dorsal Hippocampus, PFC, LHb and mHb (Figure 4A,B,E).