Thus, considering the possibility to use GAL(1-15) as a combined treatment with SSRIs to improve their effectiveness, we observed in rats that GAL(1-15) enhanced the antidepressant effects and reversed the memory impairment induced by Fluoxetine (FLX) being involved the 5-HT1AR in the hippocampus and prefrontal cortex (PFC), respectively [24,25]. Here, GAL is linked to memory impairment.