NFE2L2 and myeloid sarcoma: Interestingly, it was also shown that these neuroprotective effects were mediated via the activation of nuclear factor erythroid 2-related factor 2 (Nrf2) [162], which is a direct target of dimethyl fumarate (tecfidera), which is a first-line treatment for MS that reduces relapse rates, the number of lesions, and slows down disease progression [163].