Previous data obtained in our laboratory [18] showed that SOD1 activity is impaired by 24 h treatment with CdCl2, leading to an increased O2− level; however, toxicogenomic data showed that the SOD1 coding gene is not dysregulated by CdCl2 treatment neither in C3H cells [3] nor in human SH-SY5Y neuroblastoma cells [27]. This evidence concerns the gene SOD1 and neuroblastoma.