As our understanding of the pathogenesis of EoE increases, it is logical to anticipate that in the future further EoE risk loci will be identified, e.g., tissue—as so far defined CAPN14, or the ANKRD27, PDCD5 and RGS9BP genes [32], possibly affecting the expression of the surrounding one or more genes in the esophagus through direct effects or modulation of chromatin structure. This evidence concerns the gene CAPN14 and eosinophilic esophagitis.