SIRT6 was found to be overexpressed in skin cancer and non-small cell lung cancer (NSCLC) [168,169], osteosarcoma, colon carcinoma, serous ovarian cancer, and clear cell renal cell carcinomas (ccRCC) [169,170,171,172,173], showing a poor prognostic value. This evidence concerns the gene SIRT6 and non-small cell lung carcinoma.