RNF114 and cancer: ARTD10 has tumor suppressor activity by inhibiting myc and by the MARylation of Aurora A kinase, inhibiting its phosphorylation on the same residue: The MARylation is exerted after interacting with the ubiquitin ligase RNF114, which ubiquitylates ARTD10, activating it; a loss of RNF114 in cancers (mutation, deletion, downregulation) may lead to a loss in ARTD10 activity [1,133].