Among the genes up-regulated at the early time point by both ZNF521 or MA9, we found: (i) GFI1b, which acts as a transcriptional repressor in the hematopoietic lineage for GATA-1, Runx1, and histone deacetylase (HDAC); (ii) TAL1, which acts as a regulator of hematopoiesis and whose targets include c-Kit and UTX demethylase [45]; (iii) the TET1 gene, an oncoprotein in AML, which acts in a STAT1/TET1 axis [26,46]. This evidence concerns the gene RUNX1 and acute myeloid leukemia.