KMT2A and acute myeloid leukemia: One of the most frequent MLL translocations leading to AML results from the chromosomal translocation of t(9;11) (p21–22;q23), which fuses the MLL gene with the AF9 gene (also known as MLLT3 or LTG9) and is considered an initiating factor for leukemogenesis [3,4,5].