To delineate the effect of ZNF521 and MA9 in this model, we also focused on the genes known to promote and maintain the leukemic phenotype in MLL-AF9 leukemias, including those encoding transcription factors, epigenetic modulators, and cell cycle regulators as well as those involved in the transport or uptake of nutrients, which are summarized in Supplementary Table S1. The gene discussed is ZNF521; the disease is leukemia.