Recently, there have been two manuscripts delineating the role for ZEB1 in HSCs and their differentiation using models with Zeb1−/−, where there was an acceleration of MLL-AF9 and Meis1a/Hoxa9-driven AML progression, implicating Zeb1 as a tumor suppressor in AML LSCs [52]. Here, MLLT3 is linked to acute myeloid leukemia.