In support of the role played by SIRP-α in modulating phagocytosis, recent studies have described that the binding of SIRP-α to its receptor CD47 regulates neural networks, immune homeostasis, tumor development and induce impairment of the phagocytic capacity of alveolar macrophages after the resolution of primary bacterial or viral pneumonia, as it initiates a cascade of events leading to macrophage inhibition of phagocytosis [115,116]. This evidence concerns the gene SIRPA and viral pneumonia.