Nie et al. [59] reported a decrease in the percentage of Mφ1 (CD86+) and an increase in the ratio of CD163+/CD86+, Mφ2 in the peritoneal lavage of patients with endometriosis, especially in those with advanced disease, suggesting that the presence of retrograde menstruation into the abdominal cavity could induce an immune tolerance state of pMφ [71]. The gene discussed is CD86; the disease is endometriosis.