This NF-κB-triggered proinflammatory response in acute COVID-19 is shared with other acute respiratory viral infections caused by a highly pathogenic influenza A virus of H1N1 (e.g., Spanish flu) and H5N1 (avian flu) origin, SARS-CoV, and MERS-CoV [38]. This evidence concerns the gene NFKB1 and COVID-19.