Furthermore, various types of antiphospholipid (aPL) antibodies targeting phospholipids and phospholipid-binding proteins, including anti-cardiolipin IgG, IgM, and IgA; anti-β2 glycoprotein I IgG, IgM, and IgA; and anti-phosphatidylserine/prothrombin (aPS/PT) IgG, and IgM, were found in 52% of serum samples from 172 patients hospitalized with COVID-19. This evidence concerns the gene CD40LG and COVID-19.